Dejia Kong, Yuxing Zhang, Tongsheng Xu
Mar 1, 2016
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Abstract
Tert-butyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine- 1-carboxylate (1) is an important intermediate in many biologically active compounds such as crizotinib. In this work, compound (1) was synthesized through three steps, using tert-butyl-4-hydroxypiperdine-1-carboxylate as starting material. And the structures of tert-butyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxy late was confirmed by MS and 1 HNMR spectrum. The total yield of the three steps was 49.9%.