I. S. Zarovnaya, P. G. Dul’nev, V. Palchikov
Sep 27, 2015
Citations
0
Influential Citations
3
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
1,3-Oxazolidines exhibit versatile biological activity (anticancer, antiviral, antibacterial, anxiolytic, neurotropic) and are utilized as chiral precursors in designing optically active natural and synthetic compounds, and also as chiral ligands making possible enantioand diastereoselective processes [1–4]. Derivatives of tetrahydrothiophene 1,1-dioxide (sulfolane) do not occur naturally but are industrially available and can be used as building blocks in the syntheses of diverse biologically active heterocyclic compounds [5– 11]. Earlier only a single attempt was undertaken for annulation of oxazolidine cycle to sulfolane ring (any data confirming the structure of the product are not given) [12]. Therefore it is topical to develop preparation methods for potentially biologically active hexahydrothieno-[3,4-d][1,3]oxazole 5,5-dioxides.