Sun Tie-min
2009
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A new type of anti-TB drug of quinoline-TMC-207 derivative,6-bromo-3-[2-(6-bromo-2-methoxyquinolin-3-yl)-1,2-diphenylethyl]-2-methoxyquinoline,was synthesized from 6-bromo-3-(chlorophenylmethyl)-2-methoxyquinoline(2) by coupling reaction and the structure was confirmed by 1H NMR and HR-MS. The optimum reaction conditions at 80 ℃ for 6 h were as follows:2 was 10 mmol; Et3N was 5 mL; KI was 0.17 g; MeCN was 150 mL. The yield was 73% under the conditions.