R. Hsi, R. R. Kurtz, M. W. Moon
Nov 1, 1987
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The title compound, a 4-amino-4-arylcyclohexanone derivative with central analgesic activity, was labeled with tritium at the C-7 and C-9 positions. Deuterium labeled intermediates were used as models for developing isotope exchange and synthetic procedures. Deuterium and tritium labeled title compounds were obtained in five steps with overall yields of 18-22% from 1,4-dioxaspiro[4,5]-decan-8-one and 3-bromophenol.