S. H. Unnissa, N. Nisha, G. K. Reddy
2015
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
journal of applied pharmaceutical science
Abstract
Article history: A Series of 4-methyl-3-(5-(substituted phenyl)-4, 5-dihydro-1H-Pyrazol-3-yl) Cinnoline-6-Sulfonamide were synthesized from 4-methyl-3-acetylcinnoline-6-Sulfonamido chalcones and hydrazines. The structure of the synthesized compounds were characterized by UV, IR, NMR & Mass spectral data, and evaluated for their in vitro anti-malarial and anti-bacterial activity to get new congeners as analogs of Pyrazole based Cinnoline compounds as a potent anti-Malarial and anti-microbial agents. All analogues exhibited in vitro anti-malarial activity against Plasmodium falciparum and all the analogues showed good anti-bacterial activity against various pathogenic microbes.