Tang Xiao-hon
2014
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Journal
Chemistry & Bioengineering
Abstract
A facile and high-efficient one-pot procedure for synthesis of 2-amino-4,5,6,7-tetrahydrobenzo [b]thiophene-3-carbonitrile via Gewald′s three-component reaction with potassium carbonate as a heterogeneous solid base catalyst has been developed.The effects of catalyst dosage,reaction time and solvent type on the product yield are studied.The optimum reaction conditions are identified as follows:the catalyst dosage is 20%(molar fraction),the reaction time is 3.0hand the solvent is ethanol.This method has advantages of cheap and high-efficient catalyst,simple purification,short reaction time and high product yield.