Wang Yu-huan
2009
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Journal
Journal of Shijiazhuang Vocational Technology Institute
Abstract
The condensate(Z)-2-(2-aminothiazol-4-yl)2-(tert.-butyoxycarbonylprop-2-oxyimino) acetic acid forms 2-(2-amino-4-thiazolyl)-(Z)-2-[(1-tert-butoxycarbonyl-1-methyl-ethoxy)-imino]with DM,in alkali conditions,acetic acid benzothiazolyl thioester,by triethyl phosphate instead of the expensive triphenylphosphine.The optimum conditions were studied through the orthogonal experiment:(Z)2-(2-aminothiazol-4-yl)-2-(tert.-butyoxycarbonylprop-2-oxyimino)acetic acid 19.8 g,n((Z)-2-(2-aminothiazol-4-yl)-2-(tert.-butyoxycarbonylprop-2-oxyimino)aceticacid)∶n(DM)∶n(triethyl phosphite)∶n(triethylamine)=1∶1.2∶1.2∶1.2,with reaction solvent acetonitrile of 150 ml;reaction temperature of 5 ℃ and reaction time of 5 h.The yield of product is up to 86.8%.