Yuan Zhe-dong
2007
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
(6R,7R)-7-Benzamindo-3-chloromethyl-7-methoxy-8-oxo-5-oxa-1-azabicyclo [4.2.0] oct-2-ene-2- carboxylic acid benzhydryl ester was synthesized from 6-APA by acylation, oxidation and protection of carboxy group in one pot to give [2S-(2α,5α,6α)]-6-benzamindo-3,3-dimethyl-4,7-dioxo-4-thio-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester, which was subjected to rearrangement, chlorination and hydrolysis followed by cyclization, addi- tion, elimination and methoxylation with an overall yield of about 30%.