H. K. Pujari, B. Sharma, R. Dahiya
Feb 1, 1990
Citations
0
Influential Citations
4
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract 4-Fluoroaniline on successive acetylation, nitration and hydrolysis affords 4-fluoro-2-nitroaniline which on reduction with Raney nickel and hydrazine hydrate followed by treatment of the resulting diamine with carbon disulphide in situ gives 5-fluorobenzimidazolyl-2-thione. The thione on condensation with chloroacetic acid yields [(5-fluoro-2-benzimidazolyl)-thioe]acetic acid which on cyclization in a mixture of acetic anhydride and pyridine furnishes two isomers viz . 6-fluoro- and 7-fluorothiazolo[3,2- a ]benzimidazol-3(2 H )-ones. The condensation of thione with 1,2-dibromoethane affords sym -bis-(5-fluorobenzimidazo-2-yl-mercapto)ethane. The structural assignments for the 6-fluoro- and 7-fluorothiazolo[3,2- a ]benzimidazol-3(2 H )-ones have been made by 1H NMR spectral data using two different methods.