Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.

Paper

Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.

Published Sep 15, 1992 · J. S. Lim, K. Frenkel, W. Troll

Cancer research

Q1 SJR score

47

Citations

1

Influential Citations

Semantic Scholar

Abstract

Trans-tamoxifen (TAM) has been used successfully in therapy for estrogen-dependent human breast tumors and prevention of their recurrence. The mechanism of this prevention was thought to be due to the interference of TAM with estrogen promotion. TAM has a wider anticarcinogenic action that is similar to other chemopreventive agents in that it suppresses tumor promotion in 2-stage carcinogenesis by interfering with the action of protein kinase C. We report that TAM (5 microM) totally inhibits hydrogen peroxide (H2O2) formation by 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-treated human neutrophils. Interestingly, beta-estradiol (10 microM) also slightly inhibits the oxidative burst of neutrophils. Pretreatment of neutrophils with varying amounts of TAM and beta-estradiol caused additive inhibition of H2O2 formation by the 2 agents. 4-Hydroxy-tamoxifen, a metabolite with the highest affinity for the estrogen receptor, was only as inhibitory as beta-estradiol. Other derivatives (cis-, N-desmethyl-, and N-desdimethyl-tamoxifen) with low biological activities had a smaller effect on H2O2 formation. TPA-treated neutrophils were shown to contain 5-hydroxymethyl uracil (HMU). TAM prevented the TPA-induced formation of HMU in other cells. Like TPA, dietary fat, which is a risk factor for breast cancer, induces formation of HMU in the DNA of human white blood cells. TAM may suppress the dietary fat-induced HMU in the same manner at it does in TPA-induced neutrophils.

In Vitro Study

Study Snapshot

Tamoxifen effectively suppresses tumor promotion in 2-stage carcinogenesis by inhibiting hydrogen peroxide formation in human neutrophils, potentially benefiting breast cancer prevention and treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.

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References

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Effect of Hydrogen Peroxide on Preventing or Contributing to Polyspermic Fertilization in Sea Urchin: Modification by Tamoxifen and Macroglobulin.

Tamoxifen and macroglobulin can modify hydrogen peroxide's role in successful fertilization in sea urchins, potentially preventing polyspermic fertilization and potentially enhancing cancer prevention.

Citations

A potential chemopreventive activity of tamoxifen and amygdalin on oxidative stress in mammary carcinoma-induced in female mice.

Tamoxifen and amygdalin may effectively treat mammary carcinoma and improve oxidative stress in carcinoma tissue by decreasing serum progesterone and L-MDA concentrations.

Tamoxifen triggers the in vitro release of neutrophil extracellular traps in healthy horses

Tamoxifen's resolution of inflammation in horses with airway inflammation is due to inhibition of other neutrophilic functions, not to NET formation.

Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research

Longer-living mice show resistance to chemical carcinogenesis, and anti-aging interventions may modulate these pathways, potentially impacting the pathogenesis of mammary adenocarcinomas in older humans.

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors

Tamoxifen induces early apoptosis and inhibits respiratory burst in healthy equine neutrophils, independent of nuclear or membrane estrogen receptors.

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Tamoxifen has a direct action on equine peripheral blood neutrophils, potentially improving conditions like allergic asthma in humans and horses.

Insights into the protective mechanisms of tamoxifen in radiotherapy-induced ovarian follicular loss: impact on insulin-like growth factor 1.

Tamoxifen protects ovarian reserve and fertility in cancer survivors by increasing anti-Mullerian hormone and local IGF-1 levels and counteracting oxidative stress-mediated apoptosis.

Tamoxifen counteracts the allergic immune response and improves allergen‐induced dermatitis in mice

Tamoxifen may inhibit type I allergic reactions and improve allergen-induced dermatitis in mice, potentially benefiting patients with systemic lupus erythesus.

Acute tamoxifen treatment increases nitric oxide level but not total antioxidant capacity and adenosine deaminase activity in the plasma of rabbits.

Acute tamoxifen treatment increases nitric oxide levels in healthy rabbits, but does not affect antioxidant status or cellular immunity, but may increase nitric oxide levels as early as 24 hours after treatment.

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Selective estrogen receptor modulators (SERMs) enhance growth hormone signaling by reducing protein tyrosine phosphatase activities in HEK293 cells but have no effect on breast cancer cells.