S. Sano, Yoko Kuroda, Katsuyuki Saito
Dec 18, 2006
Citations
0
Influential Citations
27
Citations
Journal
Tetrahedron
Abstract
Abstract ( Z )-α-Fluoro-α,β-unsaturated esters ( Z )- 7a – f were stereoselectively prepared by a tandem reduction–olefination of triethyl 2-acyl-2-fluoro-2-phosphonoacetates 6a – f with NaBH 4 in EtOH. A concise synthesis of Cbz-Gly-Ψ[( Z )-CF C]-Gly ( 26 ) as a dipeptide isostere was achieved via the tandem reduction–olefination of the corresponding 2-acyl-2-fluoro-2-phosphonoacetate 20 .