Penelope A. Turner, Ellanna M. Griffin, J. Whatmore
Jan 26, 2011
Citations
0
Influential Citations
35
Citations
Journal
Organic letters
Abstract
Readily available C-acylated cycloalkanones undergo efficient Pd catalyzed ring closure/cross-coupling providing 7-substituted tetrahydroxanthones in a single operation. One of the synthesized derivatives (depicted) is shown to selectively kill pancreatic cancer (PANC-1) cells under conditions of nutrient deprivation indicating that the tetrahydroxanthone is responsible, in part, for the "antiausterity" effects of the naturally occurring kigamicins.