Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

doi:10.1039/C2GC16499J

Paper

Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

Published Jan 3, 2012 · Jun-hua Liu, Min Lei, Lihong Hu

Green Chemistry

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Abstract

A straightforward and general method has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives by simply combining 2-aminobenzimidazole or 3-amino-1,2,4-triazole, aldehyde, and β-dicarbonyl compound in the presence of a catalytic amount of thiamine hydrochloride (VB1). The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of water as the solvent that is considered to be relatively environmentally benign.

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Study Snapshot

Thiamine hydrochloride (VB1) effectively promotes the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water, offering environmental benefits and easy workup.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

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References

Efficient trans-acetoacylation mediated by ytterbium(III) triflate as a catalyst under solvent-free condition

This study presents a simple and efficient trans-acetoacylation method using ytterbium(III) triflate under solvent-free conditions for the synthesis of various -keto ester derivatives.

Highly Chemoselective Condensation of β-Naphthol, Aldehyde, and Urea Catalyzed by Thiamine Hydrochloride

Thiamine hydrochloride catalyzes a highly selective condensation reaction between -naphthol, aldehyde, and urea, with different functional groups affecting the reaction behavior.

Thiamine Hydrochloride–Catalyzed One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free Conditions

Thiamine hydrochloride (VB1) catalyzes efficient one-pot synthesis of 1,4-dihydropyridine derivatives under solvent-free conditions, with good yields from various aldehydes and easy catalyst recovery.

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.

Optimized synthesis of chromenotriazolopyrimidine series enhances MDM2-p53 inhibitors' stability, pharmacokinetics, and solubility, improving their potential for therapeutic use.

α-Zirconium Sulfophenylphosphonate as a Catalyst for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-One Derivatives Under Solvent Free Conditions

-Zirconium Sulfophenylphosphonate acts as a recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives under solvent-free conditions.

Citations

Synthesis, In Silico Study and Antimalarial Activity of Triazolo[1,5‐a]pyrimidine Derivatives

Novel triazolo[1,5-a]pyrimidine derivatives show moderate to good antimalarial activity and good pharmacokinetics profile, potentially serving as potent antimalarial agents.

Engineered anion π complex with non-covalent π interaction system and its catalytic ability on the cyclocondensation reaction of 2-aminobenzimidazole, aryl aldehyde and ethyl acetoacetate

The engineered anion complex with non-covalent interaction effectively catalyzes the cyclocondensation reaction of 2-aminobenzimidazole, aryl aldehyde, and ethyl acetoacetate, yielding 4H-pyrimi

Microwave‐assisted synthesis of benzo[4,5]imidazo[1,2‐a]pyrimidines and pyrano[4,3‐b]pyrans catalyzed by L‐glutamine functionalized magnetic nanoparticles in water:ethanol mixture

Microwave-assisted synthesis of benzo[4,5]imidazo[1,2a]pyrimidines and pyrano[4,3b]pyrans using L-glutamine functionalized nanoparticles offers efficient, cost-effective, and environmentally friendly production.

"Design, Synthesis, and Molecular Docking Analysis of Novel Benzo[4,5]imidazo[1,2-a]pyrimidine Hybrids Targeting Plasmodium falciparum DHFR: A Comprehensive In Silico and Biological Study"

Novel Benzo[4,5]imidazo[1,2-a]pyrimidine hybrids show potential as Plasmodium falciparum dihydrofolate reductase inhibitors, offering a transformative outlook for antimalarial innovation.

Green metrics in mechanochemistry.

Mechanochemical methods for organic synthesis have a lower environmental footprint compared to solution-based procedures, with precise control over stoichiometry and simplified work-up procedures.