L. Koikov, M. Polikarpov, N. Alekseeva
Oct 1, 1998
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Journal
Pharmaceutical Chemistry Journal
Abstract
The results of extensive investigations devoted to the synthesis and properties of quinuclidine compounds, conducted at the Center for Drug Chemistry (Moscow) [ 1 5], showed that di(2-thienyl)(3-qninuclidyl)carbinol hydrochloride (It), a thiophene analog of the antiallergic drugs phencarol (Ia) and bicarphen (Ib), possesses pronounced antisecretor and antiulcerous activity [6]. The previous publication [7] reported on a method developed for the synthesis of compound Ic, called quiditene, proceeding from 2-thienyllithium (II) and 3-ethoxyearbonylquinuclidine (IV):