Three-Component Reaction of 5,5-Dimethylcyclohexan-1,3-dione, Aromatic Aldehydes, and Acetonitrile in the Presence of Chlorosulfonic Acid Forming N-[(2-Hydroxy-4,4-dimethyl-6-oxocyclohexene-1-yl)-aryl-methyl]-acetamides
Published Oct 29, 2009 · M. Anary‐Abbasinejad, A. Hassanabadi, Khadije Charkhati
Synthetic Communications
Q3 SJR score
2
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0
Influential Citations
Abstract
Abstract A three-component reaction between 5,5-dimethylcyclohexan-1,3-dione (dimedone), aromatic aldehydes, and acetonitrile in the presence of chlorosulfonic acid afforded N-[(2-hydroxy-4,4-dimethyl-6-oxocyclohexene-1-yl)-aryl-methyl]-acetamides in good yields. The temperature-dependent 1H NMR of one of the products has been investigated.
Study Snapshot
Key takeawayThe three-component reaction between 5,5-dimethylcyclohexan-1,3-dione, aromatic aldehydes, and acetonitrile in the presence of chlorosulfonic acid produces N-[(2-hydroxy-4,4-dimethyl-6-oxo
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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