Paper
A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib
Published Feb 22, 2012 · Steven J. Fussell, A. Luan, P. Peach
Tetrahedron Letters
Q3 SJR score
9
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
A three-step synthesis successfully delivered multi-kilogram quantities of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK).
Crizotinib (PF-02341066) effectively inhibits c-MET kinase and ALK, effectively inhibiting tumor growth, and has good pharmaceutical properties.
2011·802citations·J. Cui et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)
A robust six-step process for the synthesis of crizotinib, a novel c-Met/ALK inhibitor, has been developed and successfully scaled-up to deliver over 100 kg of API.
2011·74citations·P. D. D. Koning et al.·Organic Process Research & Development
Organic Process Research & Development
Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for β-amyloid plaques.
Dibenzylideneacetone derivatives show high affinity for -amyloid plaques and show promising potential as a new scaffold for -amyloid imaging probes.
2011·66citations·M. Cui et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Green iodination of pyrazoles with iodine/hydrogen peroxide in water
This green iodination of pyrazoles in water produces 4-iodopyrazole derivatives with water as the only by-product, using only 0.5 equiv of iodine and 0.6 equiv of hydrogen peroxide.
2008·41citations·Mary M. Kim et al.·Tetrahedron Letters
Tetrahedron Letters
Synthesis of 8-Hydroxyquinolines with Amino and Thioalkyl Functionalities at Position 4
This study successfully synthesized six 8-hydroxyquinolines with amino and thioalkyl functionalities at position 4, achieving over 70% yield for most compounds.
2008·14citations·Walaa A E Omar et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
Citations
Epinephrine, Pregabalin, and Crizotinib as Three Medicines with Polish Implications over Three Last Centuries and in View of Three Different Drug Discovery Approaches
Polish researchers have significantly contributed to the discovery and advancement of epinephrine, pregabalin, and crizotinib, highlighting Poland's significant role in global pharmaceutical innovations and medical research.
2024·0citations·Piotr Kawczak et al.·Biomedicines
Biomedicines
Synthesis of N-Alkenylated Heterocycles via T3P-Promoted Condensation with Ketones
This study presents a convenient method for synthesizing N-alkenylated heterocycles using ketone electrophiles and T3P under microwave irradiation, offering good to excellent yields and ease of purification.
2024·1citation·Lorenzo Jacopo Ilic Balestri et al.·The Journal of Organic Chemistry
The Journal of Organic Chemistry
Synthesis and application of small molecules approved for the treatment of lymphoma.
Small molecules approved for lymphoma treatment show promise in accelerating the exploration of more potent novel medications for lymphoma management.
2023·1citation·Yuan-yuan Guo et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis.
Small molecule kinase inhibitor drugs have revolutionized cancer treatment, with 73 approved by the FDA and other regulatory agencies until 2021, and a new batch approved in 2021.
2021·140citations·Cecilia C Ayala-Aguilera et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Diffusion Control in Single-Site Zinc Reticular Amination Catalysts.
Zn-containing metal-organic frameworks show comparable activity and stability for C-Cl bond amination, avoiding basic conditions, precious metals, and additives.
2020·1citation·F. Cirujano et al.·Inorganic chemistry
Inorganic chemistry
N-[18F]-Fluoroacetylcrizotinib: A potentially potent and selective PET tracer for molecular imaging of non-small cell lung cancer.
N-[18F]-fluoroacetylcrizotinib shows potential as a promising PET tracer for non-small cell lung cancer imaging, providing non-invasive information on crizotinib's pharmacokinetics before and during clinical trials.
2020·4citations·J. Buck et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Synthesis of Tert-butyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
Tert-butyl-4-(4-(4,4,5,5-tetramethyl-1,3,2,dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1) was successfully synthesized with a total yield of 49
2016·0citations·Dejia Kong et al.
Synthetic approaches to the 2011 new drugs.
This review reviews the synthesis of 26 new drugs introduced in 2011, providing insights into molecular recognition and leads for designing future new drugs.
2013·78citations·Hong X Ding et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry