Thymidine 5'-O-pivaloate. A prodrug derivative of thymidine with potential applications in high-dose methotrexate therapy.

doi:10.1016/0006-2952(79)90470-2

Paper

DOI: 10.1016/0006-2952(79)90470-2

Thymidine 5'-O-pivaloate. A prodrug derivative of thymidine with potential applications in high-dose methotrexate therapy.

Published May 1, 1979 · W. Ensminger, A. Rosowsky

Biochemical pharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Thymidine 5'-O-pivaloate shows potential in preventing toxicity from high-dose methotrexate therapy, with increased survival in leukemic mice treated with high-dose MTX.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Thymidine is an effective rescue agent for high-dose methotrexate in humans, with mucositis and myelosuppression being the major toxicities, and DNA synthesis recovery occurring 24 hours after starting rescue.

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Citations

DOI: 10.1135/CCCC2009084

A convenient protection for 4-oxopyrimidine moieties in nucleosides by the pivaloyl group

The pivaloyl group provides rapid and efficient protection for the N3 position of thymidine and uridine, with excellent regioselectivity for sugar or thymine moiety, depending on the amines used.

2010·4citations·M. Sobkowski·Collection of Czechoslovak Chemical Communications

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Syntheses and Biological Evaluation of 5′-O-Myristoyl Derivatives of Thymidine against Human Immunodeficiency Virus

5′-O-(12-Azidododecanoyl)thymidine exhibited moderate anti-HIV activity against T4 lymphocytes, with a partition coefficient in the 4.6-4.8 range being optimal for anti-HIV activity.

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Selective pivaloylation of 2-acetamido-2-deoxy sugars, their methyl glycosides, and N-acetyl-d-muramic acid methyl -glycosides can produce various structures and acylation orders.

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