A. N. Wick, C. J. Stewart, G. Seri
May 1, 1960
Citations
0
Influential Citations
37
Citations
Journal
Diabetes
Abstract
Since the original report by Ungar et al. on the hypoglycemic action of phenethylbiguanide, now more commonly known as DBI, the in vitro effects of this drug have been extensively studied. Under certain experimental conditions it can be demonstrated that the drug will inhibit in a variety of tissues the oxidation of glucose as well as other metabolic fuels.' At the same time tissue anoxia is produced presumably by the drug's action on the electron transport system. Some of the in vitro effects of this drug have been suggested to explain its action in vivo; however, in our opinion, these studies have failed to yield any clearcut information as to how this drug lowers the blood sugar in diabetic animals. A summary of the experimental observations has been reviewed recently by Williams and Steiner.* In an attempt to shed some light on its hypoglycemic mechanism, we have labeled phenethylbiguanide with C and have conducted a time study of the urinary