G. Ellman
May 1, 1959
Citations
864
Influential Citations
22,565
Citations
Quality indicators
Journal
Archives of biochemistry and biophysics
Abstract
Abstract A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid)] has been synthesized and shown to be useful for determination of sulfhydryl groups. Several applications have been made to show its usefulness for biological materials. A study of the reaction of this disulfide with blood has produced some evidence for the splitting of disulfide bonds by reduced heme.