Top-down Enhancement and Suppression of the Magnitude and Speed of Neural Activity

doi:10.1162/0898929053279522

Paper

Top-down Enhancement and Suppression of the Magnitude and Speed of Neural Activity

Published Apr 1, 2005 · A. Gazzaley, Jeffrey W. Cooney, Kevin McEvoy

Journal of Cognitive Neuroscience

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485

Citations

17

Influential Citations

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Abstract

Top-down modulation underlies our ability to selectively attend to relevant stimuli and to ignore irrelevant stimuli. Theories addressing neural mechanisms of top-down modulation are driven by studies that reveal increased magnitude of neural activity in response to directed attention, but are limited by a lack of data reporting modulation of neural processing speed, as well as comparisons with a perceptual (passive view) baseline necessary to evaluate the presence of enhancement and suppression. Utilizing functional MRI (fMRI) and event-related potential recordings (ERPs), we provide converging evidence that both themagnitude of neural activity and thespeed of neural processing are modulated by top-down influences. Furthermore, bothenhancement andsuppression occur relative to a perceptual baseline depending on task instruction. These findings reveal the fine degree of influence that goal-directed attention exerts upon activity within the visual association cortex. We further document capacity limitations in top-down enhancement corresponding with working memory performance deficits.

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Study Snapshot

Key takeawayTop-down influences modulate both the magnitude and speed of neural activity, affecting our ability to selectively attend to relevant stimuli and ignore irrelevant stimuli.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Top-down Enhancement and Suppression of the Magnitude and Speed of Neural Activity

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References

Citations

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