Transport and uptake of nateglinide in Caco‐2 cells and its inhibitory effect on human monocarboxylate transporter MCT1

doi:10.1038/sj.bjp.0704875

Paper

Transport and uptake of nateglinide in Caco‐2 cells and its inhibitory effect on human monocarboxylate transporter MCT1

Published Oct 1, 2002 · Atsuko Okamura, Akiko Emoto, N. Koyabu

British Journal of Pharmacology

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75

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7

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Abstract

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In Vitro Study

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Study Snapshot

Nateglinide's intestinal absorption is mediated by a proton-dependent transport system distinct from MCT1, but it is not transported by MCT1.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Transport and uptake of nateglinide in Caco‐2 cells and its inhibitory effect on human monocarboxylate transporter MCT1

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References

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

MCT4 plays a crucial role in lactic acid efflux from skeletal muscle, with higher Km values and similar Vmax values than MCT1, but not pyruvate.

Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1.

The MCT1 transporter plays a major role in butyrate transport into Caco-2 cells, with its expression being highly expressed and its inhibition fully recovered within 5 days of transfection.

Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast.

MCT3 in the retinal pigment epithelium regulates lactate levels in the neural retina, with greater uptake associated with lower pH and resistance to classic inhibitors of lactate transport.

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

OATP-B, -D, and -E are novel human organic anion transporters with broad substrate specificity, while OATP-C is exclusive to the liver and exhibits high transport activity with broad substrate specificity.

Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.

Sulfonylureas and nateglinide interact with the rat renal organic anion transporter, but these drugs do not translocate via the transporter.

Citations