Treatment of hypertension with oral taurine: experimental and clinical studies

doi:10.1007/s00726-002-0212-0

Paper

Treatment of hypertension with oral taurine: experimental and clinical studies

Published 2002 · J. Militante, J. Lombardini

Amino Acids

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159

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7

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Abstract

Summary. Oral taurine treatment has been studied extensively as a hypotensive agent. Several rat models of hypertension have been used to prove that dietary taurine supplementation can alleviate high blood pressure, among other cardiovascular problems. Experimental models mentioned in this review are the spontaneously hypertensive rat, the DOCA-salt rat, the Dahl-S rat, the renovascular hypertensive rat, the hyperinsulinemic rat and the ethanol-treated rat. The beneficial effects of taurine were also demonstrated in studies involving human subjects suffering essential hypertension. Taurine supplementation of 6 g/day for as little as 7 days resulted in measurable decreases in blood pressure in these patients. In both rat and human studies, the effects of taurine appeared to be dependent on the modulation of an overactive sympathetic system. However, taurine has positive effects on other types of cardiovascular problems and thus may act through more than one mechanism.

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Study Snapshot

Oral taurine supplementation can effectively lower blood pressure in both rat models and human studies, with its effects primarily dependent on modulating an overactive sympathetic system.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Treatment of hypertension with oral taurine: experimental and clinical studies

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References

Taurine selectively modulates the secretory activity of vasopressin neurons in conscious rats

Effects of centrally administered losartan on deoxycorticosterone-salt hypertension rats.

Osmoregulation of Vasopressin Secretion via Activation of Neurohypophysial Nerve Terminals Glycine Receptors by Glial Taurine

Renin antisense injected intraventricularly decreases blood pressure in spontaneously hypertensive rats

Taurine Modulates Arginine Vasopressin‐Mediated Regulation of Renal Function

Citations

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Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

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