Paper
Tributyltin chloride leads to adiposity and impairs metabolic functions in the rat liver and pancreas.
Published May 19, 2015 · Bruno D Bertuloso, P. Podratz, E. Merlo
Toxicology letters
Q2 SJR score
88
Citations
3
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
RCT
Animal Study
Highly CitedStudy Snapshot
TBT increases adiposity in white adipose tissue and impairs metabolic functions in the rat liver and pancreas.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Obesogenic effects of endocrine disruptors, what do we know from animal and human studies?
Early life exposure to certain endocrine disrupting chemicals may be associated with weight homeostasis later in life, but not necessarily in an obesogenic direction.
2014·74citations·M. de Cock et al.·Environment international
Environment international
Tributyltin contributes in reducing the vascular reactivity to phenylephrine in isolated aortic rings from female rats.
Tributyltin (TBT) used as antifouling paint in shipping companies reduces vascular reactivity in female rats, likely due to nitric oxide bioavailability, K+ channels, and increased oxidative stress.
2014·29citations·S. Rodrigues et al.·Toxicology letters
Toxicology letters
Reduction of Fibrosis in Dibutyltin Dichloride–Induced Chronic Pancreatitis Using Rat Umbilical Mesenchymal Stem Cells From Wharton’s Jelly
Umbilical cord mesenchymal stem cells from Wharton's jelly show potential in treating chronic pancreatitis and its associated fibrosis in rats, suggesting potential as a promising therapeutic intervention for human chronic pancreatitis.
2013·32citations·Chun-hua Zhou et al.·Pancreas
Pancreas
Triiodothyronine Increases mRNA and Protein Leptin Levels in Short Time in 3T3-L1 Adipocytes by PI3K Pathway Activation
Thyroid hormone (T3) increases leptin mRNA and protein levels in 3T3-L1 adipocytes through activation of the PI3K signaling pathway.
2013·21citations·Miriane de Oliveira et al.·PLoS ONE
PLoS ONE
Decoding cell death signals in liver inflammation.
Excessive liver inflammation can cause massive cell death and exacerbate liver conditions, highlighting the need to manage inflammation and cell death.
2013·843citations·C. Brenner et al.·Journal of hepatology
Journal of hepatology
Citations
Delineating lipidomic landscapes in human and mouse ovaries: Spatial signatures and chemically-induced alterations via MALDI mass spectrometry imaging: Spatial ovarian lipidomics.
Tributyltin (TBT) exposure significantly disrupts the ovarian lipidome in mice and healthy human ovaries, potentially causing ovarian toxicity through lipid dysregulation.
2024·0citations·Natalia Pascuali et al.·Environment international
Environment international
Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature
Exposure to endocrine-disrupting chemicals, such as TCDD, PCB, TBT, phthalates, BPA, and chlorpyrifos, is linked to hypothalamic inflammation, potentially causing reproductive dysfunction.
2024·1citation·Galateia Stathori et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Tributyltin-induced visceral adiposity is associated with impaired redox balance in white adipose tissue of male rats
Subacute TBT administration leads to visceral adipose redox imbalance and increased oxidative stress in male rats, highlighting the metabolic toxic outcomes of continuous exposure to TBT in mammals.
2024·0citations·Beatriz Alexandre-Santos et al.·Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology
Addressing chemically-induced obesogenic metabolic disruption: selection of chemicals for in vitro human PPARα, PPARγ transactivation, and adipogenesis test methods
This study presents a comprehensive chemical selection list for developing, optimizing, and validating test methods for assessing chemically-induced obesogenic metabolic disruption.
2024·1citation·E. Ozcagli et al.·Frontiers in Endocrinology
Frontiers in Endocrinology
Subacute exposure to a mixture of tributyltin plus mercury impairs reproductive axis function, exacerbating premature ovarian insufficiency features and reducing fertility in female rats.
Exposure to a mixture of tributyltin and mercury impairs reproductive axis function, exacerbating premature ovarian insufficiency features and reducing fertility in female rats.
2024·1citation·C. D. F. Januario et al.·Reproductive toxicology
Reproductive toxicology
Subacute tributyltin exposure alters the development and morphology of mammary glands in association with CYP19A1 expression in female rats.
Subacute tributyltin exposure impairs mammary gland development in female rats by modulating CYP19A1 signaling pathways.
2024·0citations·Natalia P. Silva et al.·Reproductive toxicology
Reproductive toxicology
Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats.
Subacute cadmium exposure impairs white adipose tissue, liver, pancreas, and skeletal muscle function, leading to type 1 and 2 diabetes mellitus features and other complications in female rats.
2024·3citations·C. S. da Costa et al.·Environmental toxicology
Environmental toxicology
Maternal exposure to tributyltin alters the breast milk, hormonal profile, and thyroid morphology of dams and induces sex-specific changes in neonate rat offspring.
Maternal exposure to tributyltin alters breast milk, hormonal profile, and thyroid morphology in dams, and induces sex-specific changes in neonate rat offspring.
2024·0citations·R. A. Miranda et al.·Environmental pollution
Environmental pollution