Yulin Zhu, Yuan-jiang Pan, Shenlin Huang
Jan 1, 2004
Citations
1
Influential Citations
37
Citations
Journal
Synthetic Communications
Abstract
Abstract Trimethylsilyl chloride (TMSCl) was used as a Lewis acid to efficiently perform one‐pot, three‐components, Biginelli condensation reactions of aldehydes, 1,3‐dicarbonyl compounds, and urea or thiourea. This resulted in simple one‐pot synthesis of the corresponding 3,4‐dihydropyrimidin‐ 2(1H)‐ones at room temperature with excellent yield.