Tris(1,3-dichloro-2-propyl)phosphate Reduces Growth Hormone Expression via Binding to Growth Hormone Releasing Hormone Receptors and Inhibits the Growth of Crucian Carp.

doi:10.1021/acs.est.0c07708

Paper

Tris(1,3-dichloro-2-propyl)phosphate Reduces Growth Hormone Expression via Binding to Growth Hormone Releasing Hormone Receptors and Inhibits the Growth of Crucian Carp.

Published Jun 1, 2021 · Yongkang Zhang, Xun'e Yi, Kai Huang

Environmental science & technology

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16

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0

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Abstract

Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) has commonly been used as an additive flame retardant and frequently detected in the aquatic environment and in biological samples worldwide. Recently, it was found that exposure to TDCIPP inhibited the growth of zebrafish, but the relevant molecular mechanisms remained unclear. In this study, 5 day-old crucian carp (Carassius auratus) larvae were treated with 0.5, 5, or 50 μg/L TDCIPP for 90 days; the effect on growth was evaluated; and related molecular mechanisms were explored. Results demonstrated that 5 or 50 μg/L TDCIPP treatment significantly inhibited the growth of crucian carp and downregulated the expression of growth hormones (ghs), growth hormone receptor (ghr), and insulin-like growth factor 1 (igf1). Molecular docking, dual-luciferase reporter gene assay, and in vitro experiments demonstrated that TDCIPP could bind to the growth hormone releasing hormone receptor protein of crucian carp and disturb the stimulation of growth hormone releasing hormone to the expression of ghs, resulting in the decrease of the mRNA level of gh1 and gh2 in pituitary cells. Our findings provide new perceptions into the molecular mechanisms of developmental toxicity of TDCIPP in fish.

In Vitro Study

Study Snapshot

TDCIPP inhibits crucian carp growth by binding to growth hormone releasing hormone receptors, disrupting growth hormone stimulation and causing a decrease in growth hormone mRNA levels in pituitary cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Tris(1,3-dichloro-2-propyl)phosphate Reduces Growth Hormone Expression via Binding to Growth Hormone Releasing Hormone Receptors and Inhibits the Growth of Crucian Carp.

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References

Citations

A Novel Organophosphate Ester, Tris(2,4-ditert-butylphenyl) Phosphate, Induced Reproductive Toxicity in Male Zebrafish at Environmentally Relevant Concentrations.

TDtBPP exposure at environmentally relevant levels inhibits spermatogenesis and androgen synthesis in male zebrafish, leading to decreased fecundity and reproductive toxicity.

Microcystin-LR induces fatty liver metabolic disease in zebrafish through the PPARα-NOD1 pathway: In vivo, in vitro, and in silico investigations.

Microcystin-LR-induced nonalcoholic steatohepatitis in zebrafish is mediated by PPAR and NOD1, offering insights into its mechanism and potential health risks.

Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway.

Nanoplastics can exacerbate the neurodevelopmental toxicity of TDCIPP in zebrafish offspring, potentially through the involvement of the dopamine signaling pathway.

Organophosphorus flame retardants in fish from the middle reaches of the Yangtze River: Tissue distribution, age-dependent accumulation and ecological risk assessment.

Organophosphorus flame retardants (OPFRs) are present in both crucian carp and silver carp from the Yangtze River, with TDCIPP being the main contributor (>50%), and both species are at medium to high ecological risk.

Functionalization of seawater reverse osmosis membrane with quorum sensing inhibitor to regulate microbial community and mitigate membrane biofouling.

Incorporating methyl anthranilate (MA) into seawater reverse osmosis membranes effectively reduces biofouling by over 80% and improves long-term stability.

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EHDPP exposure at environmental concentrations can cause thyroid hormone disruption in zebrafish larvae, leading to decreased thyroid hormone levels and altered thyroid development.

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Metabolic disrupting chemicals (MDCs) negatively impact hormone metabolism, redox homeostasis, energy sensors, and receptor modulation in both fish and mammals, potentially leading to metabolic imbalance and obesity.

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Organophosphate esters (OPEs) pose low but not negligible risks to human health in various aquatic environments, with concentrations varying widely across surface water, drinking water, and wastewater.