Paper
Tumor delivery of macromolecular drugs based on the EPR effect.
Published Mar 18, 2011 · V. Torchilin
Advanced drug delivery reviews
Q1 SJR score
1,797
Citations
27
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
The EPR effect plays a crucial role in intratumoral delivery of macromolecular drugs and pharmaceutical nanocarriers, offering potential new treatment options.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA.
Grafting PEG to poly-lysine increases its lifetime in blood circulation and tumor accumulation without affecting its ability to associate with siRNA.
2011·60citations·Arihiro Kano et al.·Journal of controlled release : official journal of the Controlled Release Society
Journal of controlled release : official journal of the Controlled Release Society
Solid lipid nanoparticles for applications in gene therapy: a review of the state of the art
Cationic SLNs show potential for gene therapy, but their success depends on efficiently targeting specific cell types and expressing therapeutic genes.
2010·83citations·M. Bondì et al.·Expert Opinion on Drug Delivery
Expert Opinion on Drug Delivery
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
Nitroglycerin application enhances the delivery of macromolecular antitumor drugs to tumors, potentially increasing their therapeutic effects without causing toxicity.
2009·175citations·T. Seki et al.·Cancer Science
Cancer Science
Elevating blood pressure as a strategy to increase tumor-targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors.
Elevating blood pressure using angiotensin II can enhance tumor-targeted delivery of SMANCS, improving therapeutic response and reducing toxicity in advanced solid tumors.
2009·159citations·A. Nagamitsu et al.·Japanese journal of clinical oncology
Japanese journal of clinical oncology
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.
Introducing a pH-sensitive fusogenic GALA peptide and PPD into the MEND enhances the efficiency of siRNA delivery and gene silencing in vitro and in vivo.
2009·244citations·H. Hatakeyama et al.·Journal of controlled release : official journal of the Controlled Release Society
Journal of controlled release : official journal of the Controlled Release Society
Ligand‐Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues
Ligand-targeted delivery of siRNA to malignant cells and tissues can effectively overcome delivery issues and enhance potential clinical applications of siRNA in cancer treatment.
2009·73citations·Mini Thomas et al.·Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo.
The "wrapsome" nanoparticle system effectively inhibits tumor growth by targeting specific genes within tumors, with no significant acute or long-term toxicity.
2009·92citations·N. Yagi et al.·Cancer research
Cancer research
Tumor-Targeted Nanomedicines: Enhanced Antitumor Efficacy In vivo of Doxorubicin-Loaded, Long-Circulating Liposomes Modified with Cancer-Specific Monoclonal Antibody
Doxorubicin-loaded liposomes modified with cancer-specific monoclonal antibody 2C5 significantly enhance tumor accumulation and therapeutic efficacy, resulting in reduced tumor weights compared to control treatments.
2009·172citations·T. Elbayoumi et al.·Clinical Cancer Research
Clinical Cancer Research
Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect.
Polymeric drugs with the EPR-effect can effectively target and deliver anticancer drugs to solid tumors, potentially improving cancer chemotherapy.
2009·1097citations·H. Maeda et al.·European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Citations
Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine
Transition metal complexes show promise in cancer diagnosis and treatment, antibacterial, antifungal, antiviral, and antiparasitic activities, and neurological disease treatment.
2025·0citations·S. Abdolmaleki et al.·Coordination Chemistry Reviews
Coordination Chemistry Reviews
Transforming cancer immunotherapy: Overcoming immunosuppression in tumors via gene silencing techniques based on nanoparticles
Nanoparticle-based gene silencing techniques show promise in improving cancer immunotherapy by targeting immunosuppressive cells and overcoming challenges in therapeutic gene stability and transfection.
2025·0citations·Pranoy Saha et al.·Journal of Drug Delivery Science and Technology
Journal of Drug Delivery Science and Technology
HSV-1 virions and related particles: biogenesis and implications in the infection.
HSV-1 infection produces diverse particles, with their type and composition shaped by the virus's ability to evade host responses, shaping the infectious microenvironment and influencing disease outcomes.
2025·0citations·M. Kalamvoki·Journal of virology
Journal of virology
Smart Mesoporous Silica Nanoparticles in Cancer: Diagnosis, Treatment, Immunogenicity, and Clinical Translation.
Mesoporous silica nanoparticles (MSNs) offer targeted cancer treatment and diagnosis, enhancing therapeutic effectiveness while minimizing adverse effects on healthy cells.
2025·0citations·Satar Yousefiasl et al.·Small
Small
Recent advances on brain drug delivery via nanoparticles: alternative future materials for neuroscience applications; a review.
Nanoparticles show promise in selectively delivering drugs to the central nervous system, overcoming the blood-brain barrier and serving as effective imaging contrast agents for brain tumor treatment.
2025·0citations·Razieh Razavi et al.·Reviews in the neurosciences
Reviews in the neurosciences
Unraveling the in vivo pharmacokinetic behavior of mPEG5-NH2 polymer in rats by UHPLC-MS/MS assay.
The UHPLC-MS/MS assay effectively reveals the in vivo pharmacokinetic behavior of mPEG5-NH2 polymer in rats, aiding in understanding its toxicity and efficiency in drug delivery systems.
2025·0citations·Yingxia Guo et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences