Uncoupling effect of the general anesthetic 2,6-diisopropylphenol in isolated rat liver mitochondria.

doi:10.1016/0003-9861(91)90575-4

Paper

DOI: 10.1016/0003-9861(91)90575-4

Uncoupling effect of the general anesthetic 2,6-diisopropylphenol in isolated rat liver mitochondria.

Published Nov 1, 1991 · D. Branca, M. Roberti, E. Vincenti

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In Vitro Study

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2,6-diisopropylphenol reduces ATP synthetase activity in isolated rat liver mitochondria without affecting ATP production, acting as a mild protonophore.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1101/2024.09.12.612245

The preferential injury of outer renal medulla after ischemia-reperfusion relies on high oxidative metabolism

Propofol impairs renal mitochondrial function, worsening tubular injury during ischemia-reperfusion in the outer renal medulla.

2024·0citations·Grégoire Arnoux et al.·bioRxiv

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Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model.

Propofol overdose causes hematological cytotoxicity and immune cell alteration in an ex vivo model, particularly affecting neutrophils and granulocytes.

2023·1citation·C. Hsing et al.·Toxicology in vitro : an international journal published in association with BIBRA

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A Commentary on the Effect of Targeted Temperature Management in Patients Resuscitated from Cardiac Arrest.

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Kinetic characteristics of propofol-induced inhibition of electron-transfer chain and fatty acid oxidation in human and rodent skeletal and cardiac muscles

Propofol-induced inhibition of bioenergetic pathways in human skeletal and cardiac muscles is more marked than in rodent tissues, with a potential link to Propofol Infusion Syndrome.

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The Basic Study of the Mechanism of Propofol-Related Infusion Syndrome Using a Murine Skeletal Muscle Injury Model

Propofol-related infusion syndrome (PRIS) is caused by dose-dependent cell damage to the mitochondrial electron transport chain and metabolic disorders, providing a potential experimental model for further investigations.

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Propofol infusion syndrome is a rare, potentially fatal condition with different clinical features in children and adults, and should be considered in cases of unexplained metabolic acidosis, ECG changes, and rhabdomyolysis.

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