Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives.

doi:10.1248/cpb.c18-00482

Paper

Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives.

Published Oct 1, 2018 · H. El-Mawgoud, S. R. Atta-Allah, M. Hemdan

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Abstract

The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references.

Study Snapshot

2-(thiophene-2-carbonylcarbamothioylthio)acetic acid is a promising synthon for synthesis of new thiazole and annulated thiazole derivatives, with potential antimicrobial activity against various microorganisms.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives.

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References

Clinical and Pathogenic Microbiology

This edition provides comprehensive coverage of bacteriology, mycology, parasitology, and virology, with new and revised chapters on biosafety, molecular diagnostic methods, mycoplasma, and retroviruses.

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