Paper
THE USES OF 4-PHENYL-3-THIOSEMICARBAZIDE IN HETEROCYCLIC SYNTHESIS: NOVEL SYNTHESIS OF THIAZOLE, PYRAZOLE AND 1,3,4-THIADIAZINE DERIVATIVES
Published Nov 1, 1992 · R. Mohareb, H. Shams, Y. M. Elkholy
Phosphorus Sulfur and Silicon and The Related Elements
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Abstract
Abstract 4-Phenyl-3-thiosemicarbazide derivatives 1a-c react with phenacylbromide, 3-bromoacetylcoumarin and monochloroacetic acid to afford thiazole derivatives 3a-c, 8a-c and 12a-c respectively. Reaction of 1a with ethyl acetoacetate afford the condensated product 17. Reaction of 3a-c and 8a-c with aromatic diazonium salts afford the 5-arylazothiazole derivatives 5a-f and 9a-f respectively. Most of the synthesized products show high fungicidal and bactericidal activities.
4-Phenyl-3-thiosemicarbazide derivatives can be used in heterocyclic synthesis to produce fungicidal and bactericidal compounds with high fungicidal and bactericidal activities.
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