R. Mohareb, M. S. Gamaan
Nov 26, 2018
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Bulletin of The Chemical Society of Ethiopia
Abstract
In the present work, the ethyl 2-(1 H -benzo[ d ]imidazol-2-yl)acetate ( 3 ) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[ d ]imidazole moiety. All the synthesized compounds were determined by elemental analysis, 1 H NMR, 13 C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a , 9b , 9c , 17 , 23b and 38 were of the highest potencies among the synthesized compounds. KEY WORDS : Oxobutanamide, Thiophene, Pyrazole, Pyran, Pyridine Bull. Chem. Soc. Ethiop. 2018 , 32(3), 541-557. DOI: https://dx.doi.org/10.4314/bcse.v32i3.13