B. Das, M. Krishnaiah, V. S. Reddy
Nov 1, 2007
Citations
0
Influential Citations
14
Citations
Journal
Helvetica Chimica Acta
Abstract
Treatment of different types of alcohols with tetrahydrofuran (THF) in the presence of VCl3 and CCl4 smoothly afforded the corresponding THF-based acetals in excellent yields. The reaction is fast at room temperature, and several functional groups are tolerated, with no racemization being observed. A radical mechanism, based on Cl3C. as the active species, is proposed for this novel kind of transformation, which complements the classical tetrahydro-2H-pyran-2-yl (THP) protocol.