Masayuki Nakamura, K. Niiyama, T. Yamakawa
Nov 25, 2009
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron Letters
Abstract
A versatile method for the synthesis of 4-substituted 6-methyl-3-oxabicyclo[3.3.1]non-6-ene-1-methanol derivatives has been developed using Prins-type cyclization reaction between aldehydes and O-protected/unprotected cyclohex-3-ene-1,1-dimethanol. Under optimized reaction conditions using hafnium triflate, various substrates, including functionalized benzaldehydes and heteroaromatic carbaldehydes, afforded cyclization products in high yields.