V. J. Majo, P. Perumal
Sep 29, 1997
Citations
0
Influential Citations
27
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of 5-aryloxazole-4-carboxaldehydes was accomplished by an unprecedented Vilsmeier cyclization of 2-azidoacetophenones. One-pot synthesis of these oxazolecarboxaldehydes from 2-bromoacetophenones by dehaloazidation-Vilsmeier cyclization reaction sequence provided better yields. The treatment of 2-azidoacetophenones with Vilsmeier reagent (DMF/POCl 3 ) at rt resulted in the exclusive formation of α-azido-β-chlorovinyl azides in moderate yields.