In vivo and in vitro analysis of low level light therapy: a useful therapeutic approach for sensitive skin

doi:10.1007/s10103-013-1281-x

Paper

In vivo and in vitro analysis of low level light therapy: a useful therapeutic approach for sensitive skin

Published Feb 10, 2013 · M. Choi, J. Kim, K. Cho

Lasers in Medical Science

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20

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0

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Abstract

Sensitive skin is a relatively common dermatologic condition and no optimal treatments have been established so far. Low-level laser/light therapy (LLLT) has been used for its biostimulative effect in various clinical settings. The purpose of this study was to investigate whether low-level laser/light therapy can improve sensitive skin clinically and to evaluate the effects of LLLT on skin in vitro. Twenty-eight patients complaining of sensitive skin were treated with low-level polarized light, and clinical results were evaluated using subjective and objective method. To investigate possible working mechanism of LLLT on skin, cultured human keratinocytes pretreated with nontoxic concentration of sodium lauryl sulfate (SLS) were used. Cytokines released from irritated keratinocytes after LLLT were analyzed. All patients showed subjective and objective improvement after treatment. No adverse effects were reported. The average number of LLLT sessions required to achieve clinical improvement was 9.9, and cumulative dose of LLLT was 71.3 J/cm2 on the average. Erythema index decreased significantly after LLLT treatment (p = 0.017). In vitro assay showed that LLLT significantly reduced the release of VEGF from SLS-pretreated keratinocytes (p = 0.021). Our results suggest that LLLT could be a useful and safe treatment modality for sensitive skin, and modification of inflammatory cytokines released from irritated keratinocytes may be considered as one of plausible mechanisms in sensitive skin treated with LLLT.

In Vitro Study

Study Snapshot

Low-level laser/light therapy (LLLT) is a useful and safe treatment for sensitive skin, potentially reducing inflammatory cytokines and reducing erythema index.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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In vivo and in vitro analysis of low level light therapy: a useful therapeutic approach for sensitive skin

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References

Low Level Light Could Work on Skin Inflammatory Disease: A Case Report on Refractory Acrodermatitis Continua

Low level polarized polychromatic noncoherent light (LPPL) effectively treats inflammatory skin conditions without side effects, as demonstrated in a case of acrodermatitis continua in a pregnant woman.

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Laser irradiation can modulate cellular proliferation in a wavelength- and dosage-dependent manner, but the relevance of other key irradiation parameters remains unclear.

Laser photobiomodulation of wound healing: a review of experimental studies in mouse and rat animal models.

Laser or monochromatic light therapy can effectively photobiomodulate wound healing processes in experimental wounds in rats and mice, supporting the need for further controlled research in humans.

Laser photobiomodulation of wound healing in diabetic and non-diabetic mice: effects in splinted and unsplinted wounds.

Laser irradiation stimulates healing in splinted wounds in diabetic mice, improving re-epithelization and granulation tissue formation.

Sensitive skin: closing in on a physiological cause

Sensitive skin may be caused by biophysical changes in the skin, with current research supporting a biophysical origin for this disorder.

Citations

Low‐Energy Delicate Pulsed Light Therapy for Sensitive Skin: A Retrospective Study

Low-energy delicate pulsed light (DPL) is an effective and safe treatment for sensitive skin, improving facial redness and skin color without causing obvious adverse effects.

Photobiomodulation induces microvesicle release in human keratinocytes: PI3 kinase-dependent pathway role

Laser-induced microvesicle release from human keratinocytes may accelerate wound healing by promoting cell-to-cell communication and promoting wound healing through PI-3 kinase-dependent pathways.

Sensitive Skin in the Population of Herzegovina-Neretva County: Prevalenceand Clinical Data.

Sensitive skin affects nearly half of the population in Herzegovina-Neretva County, with higher prevalence in females and a burden on quality of life.

An herbal cream reduces erythema of sensitive skin

The herbal cream effectively reduces erythema and improves the quality of life for sensitive skin.

Efficacy and Tolerability of Phototherapy With Light-Emitting Diodes for Sensitive Skin: A Pilot Study

Phototherapy with LEDs effectively reduces sensitive skin symptoms and improves tolerance in subjects without other facial skin disorders, with benefits persisting for 2 months after the last session.