Yueju Li, F. Liang
Jun 29, 2016
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
Abstract We have demonstrated that N -haloimides can be utilized as an aminating reagent, in addition to the traditional brominating reagent. Herein, the P–N cross-coupling of P(O)–H compounds and N -bromophthalimide has been developed with the DBU activation strategy. The nitrogen source may arise from internal N -bromophthalimide itself (a self-immolating reagent) or external phthalimide derivatives (with NBS-DBU activation system). The reaction features broad phosphorous compounds scope, including H -phosphinates, H -phosphonates, and H -phosphine oxides, and short reaction time (less than 10 min). This method provides a simple, convenient, efficient, and green route toward phosphoramidates which are of biological importance under mild conditions.