Mustapha Mandewale, Santosh Kokate, B. Thorat
Jul 30, 2016
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Influential Citations
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Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
Abstract A series of hydrazone derivatives 5a – 5i were synthesized through multi-step reactions. The 2-(2-oxo-1,2,3,4-tetrahydroquinoline-7-yloxy)acetohydrazide was prepared from 7-hydroxy-3,4-dihydroquinolin-2(1H)-one as starting material. Then the condensation of 2-(2-oxo-1,2,3,4-tetrahydroquinoline-7-yloxy)acetohydrazide with different o-hydroxyaldehyde derivatives 4a – 4i yielded into hydrazone derivatives 5a – 5i . These hydrazone ligands were complexed with Zn (II) yielded complexes 6a – 6i . The molecular structures of the hydrazones 5a – 5i and Zn (II) complexes 6a – 6i were characterized by FTIR, 1 H and 13 C NMR, LCMS, XRD, DSC-TGA, UV–Visible, Fluorescence and elemental analysis. The conductivity experiments showed that all the complexes are non-electrolytes.The Preliminary results of antituberculosis study showed that most of the Zn (II) complexes 6a – 6i demonstrated very good antituberculosis activity while the ligands 4a – 4i showed moderate activity. Among the tested compounds 6c , 6e and 6h were found to be most active with minimum inhibitory concentration (MIC) of 1 . 6 μg/mL against Mycobacteriumtuberculosis (H37 RV strain) ATCC No.-27294 which is comparable to ‘‘first and second line’’ drugs used to treat tuberculosis.