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These studies suggest that ketamine therapy can help with depression, particularly treatment-resistant depression, with rapid and significant antidepressant effects, though more research is needed to confirm its long-term efficacy and safety.
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Ketamine, a dissociative anesthetic, has garnered significant attention for its potential rapid antidepressant effects, particularly in treatment-resistant depression (TRD). This synthesis examines the efficacy, safety, and duration of ketamine's antidepressant effects based on multiple research studies.
Rapid Antidepressant Effects:
Efficacy in Treatment-Resistant Depression:
Safety and Tolerability:
Administration and Dosage:
Comparison with Other Treatments:
Ketamine demonstrates rapid and significant antidepressant effects, particularly in treatment-resistant depression, with effects noticeable within 24 hours and lasting up to 1-2 weeks. It is generally well-tolerated with mild, transient side effects. Both racemic ketamine and esketamine are effective, with racemic ketamine potentially offering slightly higher response rates. Further research is needed to explore long-term efficacy, optimal dosing schedules, and the potential of other glutamatergic agents.
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