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These studies suggest that Marburg virus disease can be treated with a combination of supportive care, experimental therapies such as lipid nanoparticle-delivered siRNA and remdesivir, and various chemical therapeutics, while also highlighting the importance of molecular detection and vaccines for prevention and diagnosis.
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Marburg virus disease (MVD) is a severe and often fatal illness caused by the Marburg virus, a member of the Filoviridae family. Despite the high mortality rates associated with MVD, there are currently no approved vaccines or drugs for human use to treat this infection.
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In conclusion, while there is no specific approved treatment for Marburg virus disease in humans, research indicates potential therapeutic options. Lipid nanoparticle-encapsulated siRNA and the antiviral drug remdesivir have shown promise in nonhuman primate studies. Various chemical therapeutic options may offer symptomatic relief, and supportive care remains critical for managing the disease. Additionally, monoclonal antibodies and vaccine candidates are being explored as potential preventive and therapeutic measures.
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