How much Mushroom Extracts should I take daily?
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Optimal Daily Dosage of Mushroom Extracts
White Button Mushroom Extract Dosage for Breast Cancer Prevention
Research on the white button mushroom (Agaricus bisporus) has shown promising results in the context of breast cancer prevention. A clinical trial aimed to determine the optimal dose of white button mushroom extract for postmenopausal breast cancer survivors found that doses up to 13 grams per day were well tolerated1. The study involved administering 5, 8, 10, or 13 grams of mushroom extract daily over a 12-week period. The results indicated that while no patients met the pre-defined response criterion of a 50% decrease in free estradiol, doses of 10 grams and 13 grams per day were effective in stabilizing estradiol levels and suppressing post-prandial fluctuations in aromatase activity1. Therefore, a daily intake of 10 to 13 grams of white button mushroom extract appears to be optimal for achieving these effects.
Maitake Mushroom Extract for Immune Function
The Maitake mushroom (Grifola frondosa) has been studied for its immunomodulatory properties. In a phase I/II dose escalation trial, breast cancer patients were given Maitake liquid extract at doses ranging from 0.1 to 5 mg/kg twice daily for three weeks2. The study found that the extract was generally well tolerated, with no dose-limiting toxicity observed. However, the immunological effects varied with the dose, showing both stimulatory and inhibitory effects on immune function. The dose-response curves were non-monotonic, indicating that intermediate doses might have different effects compared to both high and low doses2. This suggests that the optimal dosage for immune function may vary, and patients should be cautious and consult healthcare providers for personalized recommendations.
Selenium-Enriched Mushroom Extract for Daily Selenium Intake
Selenium-enriched mushroom aqueous enzymatic extracts (MAEE) from the white button mushroom have been developed to provide a convenient source of selenium. With a selenium concentration of 51.8 µg/g, consuming around 1 gram of this extract can meet the recommended daily dose of 55 µg of selenium3. This small amount can be easily incorporated into various foods without altering their taste or texture, making it a practical option for those looking to increase their selenium intake for the prevention of diseases associated with low selenium levels, such as neurodegenerative and cardiovascular diseases3.
Conclusion
In summary, the optimal daily dosage of mushroom extracts varies depending on the type of mushroom and the intended health benefit. For white button mushroom extract aimed at breast cancer prevention, a daily intake of 10 to 13 grams is recommended. For Maitake mushroom extract, the dosage can range from 0.1 to 5 mg/kg twice daily, but the effects on immune function can vary, necessitating personalized medical advice. For selenium intake, 1 gram of selenium-enriched mushroom extract is sufficient to meet the daily recommended dose. Always consult with healthcare professionals before starting any new supplement regimen.
Sources and full results
Most relevant research papers on this topic
A dose-finding clinical trial of mushroom powder in postmenopausal breast cancer survivors for secondary breast cancer prevention.
High doses of white button mushroom extract are well-tolerated and may suppress post-prandial fluctuations in estrogen levels, but not enough to significantly reduce estrogen levels from baseline in 12 weeks.
Non-RCT
Rigorous JournalA phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects
Oral administration of Maitake mushroom extract shows both stimulatory and inhibitory effects in peripheral blood, suggesting botanical agents may both enhance and suppress immune function in breast cancer patients.
RCTRigorous Journal
Highly CitedPreparation and characterisation of selenium-enriched mushroom aqueous enzymatic extracts (MAEE) obtained from the white button mushroom (Agaricus bisporus)
MAEE from white button mushrooms can effectively achieve the recommended daily dose of 55 g selenium without affecting organoleptic properties, aiding in the treatment and prevention of diseases linked to low selenium levels.
Anti-inflammatory properties of edible mushrooms: A review.
Edible mushrooms are rich in anti-inflammatory components, offering therapeutic and health-promoting benefits, making them a valuable constituent of the daily diet for diseases associated with inflammation.
Literature ReviewHighly CitedDietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study.
Mushroom mycelium extract was ineffective in reducing prostate specific antigen levels in early prostate cancer patients managed expectantly.
Non-RCTDaily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats.
Daily supplementation with 0.5% mushroom improves balance and working memory in aged rats, suggesting potential benefits for cognitive and motor function in humans.
RCT
Animal StudyEvaluation of the bioavailability of vitamin D2 in mushrooms in healthy adults
Ingesting mushrooms containing vitamin D2 is as effective as supplemental D2 and D3 for increasing and maintaining serum 25(OH)D levels in healthy adults.
RCTAntioxidant activity and total phenolics of edible mushroom extracts
Edible mushrooms, particularly Shiitake mushrooms, show potential as natural antioxidants due to their high phenolic content and antioxidant activity.
Highly CitedNatural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.
ABMK consumption improves natural killer cell activity and quality of life in gynecological cancer patients undergoing chemotherapy, while not significantly affecting lymphokine-activated killer and monocyte activities.
RCTHighly CitedErgocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults.
UV-treated white button mushrooms and ergocalciferol supplements can increase vitamin D levels in healthy adults, but 25(OH)D3 levels decrease proportionally.
RCT
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