How much Mushroom Extracts should I take daily?
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Optimal Daily Dosage of Mushroom Extracts
White Button Mushroom Extract Dosage for Breast Cancer Prevention
Research on the white button mushroom (Agaricus bisporus) has shown promising results in the context of breast cancer prevention. A clinical trial aimed to determine the optimal dose of white button mushroom extract for postmenopausal breast cancer survivors found that doses up to 13 grams per day were well tolerated. The study involved administering 5, 8, 10, or 13 grams of mushroom extract daily over a 12-week period. The results indicated that while no patients met the pre-defined response criterion of a 50% decrease in free estradiol, doses of 10 grams and 13 grams per day were effective in stabilizing estradiol levels and suppressing post-prandial fluctuations in aromatase activity. Therefore, a daily intake of 10 to 13 grams of white button mushroom extract appears to be optimal for achieving these effects.
Maitake Mushroom Extract for Immune Function
The Maitake mushroom (Grifola frondosa) has been studied for its immunomodulatory properties. In a phase I/II dose escalation trial, breast cancer patients were given Maitake liquid extract at doses ranging from 0.1 to 5 mg/kg twice daily for three weeks. The study found that the extract was generally well tolerated, with no dose-limiting toxicity observed. However, the immunological effects varied with the dose, showing both stimulatory and inhibitory effects on immune function. The dose-response curves were non-monotonic, indicating that intermediate doses might have different effects compared to both high and low doses. This suggests that the optimal dosage for immune function may vary, and patients should be cautious and consult healthcare providers for personalized recommendations.
Selenium-Enriched Mushroom Extract for Daily Selenium Intake
Selenium-enriched mushroom aqueous enzymatic extracts (MAEE) from the white button mushroom have been developed to provide a convenient source of selenium. With a selenium concentration of 51.8 µg/g, consuming around 1 gram of this extract can meet the recommended daily dose of 55 µg of selenium. This small amount can be easily incorporated into various foods without altering their taste or texture, making it a practical option for those looking to increase their selenium intake for the prevention of diseases associated with low selenium levels, such as neurodegenerative and cardiovascular diseases.
Conclusion
In summary, the optimal daily dosage of mushroom extracts varies depending on the type of mushroom and the intended health benefit. For white button mushroom extract aimed at breast cancer prevention, a daily intake of 10 to 13 grams is recommended. For Maitake mushroom extract, the dosage can range from 0.1 to 5 mg/kg twice daily, but the effects on immune function can vary, necessitating personalized medical advice. For selenium intake, 1 gram of selenium-enriched mushroom extract is sufficient to meet the daily recommended dose. Always consult with healthcare professionals before starting any new supplement regimen.
Sources and full results
Most relevant research papers on this topic
A dose-finding clinical trial of mushroom powder in postmenopausal breast cancer survivors for secondary breast cancer prevention.
A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects
Preparation and characterisation of selenium-enriched mushroom aqueous enzymatic extracts (MAEE) obtained from the white button mushroom (Agaricus bisporus)
Anti-inflammatory properties of edible mushrooms: A review.
Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study.
Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats.
Evaluation of the bioavailability of vitamin D2 in mushrooms in healthy adults
Antioxidant activity and total phenolics of edible mushroom extracts
Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.
Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults.
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