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These studies suggest that Nanog expression decreases during the differentiation of embryonic stem cells, with variability and regulation by pathways and epigenetic factors influencing this process.
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Nanog is a critical transcription factor involved in maintaining the pluripotency and self-renewal of embryonic stem cells (ESCs). Understanding how Nanog expression changes during the differentiation of ESCs is essential for insights into stem cell biology and potential therapeutic applications.
Downregulation of Nanog During Differentiation:
Heterogeneous Expression Patterns:
Transient Upregulation During Early Differentiation:
Epigenetic Regulation:
Biallelic and Variable Expression:
Nanog expression is crucial for maintaining the pluripotency of ESCs and is tightly regulated during differentiation. It is generally downregulated as ESCs differentiate, although there is a transient upregulation during early differentiation stages. The expression of Nanog is heterogeneous, with lower levels predisposing cells to differentiation. This heterogeneity is regulated by both genetic and epigenetic mechanisms, including the action of Ezh2. Understanding these dynamics provides valuable insights into the control of stem cell differentiation and the maintenance of pluripotency.
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