How is salmonella infection treated?

Introduction: Salmonella infection, a common bacterial disease affecting the intestinal tract, poses significant health challenges worldwide. Treatment strategies for this infection have evolved over time, with a focus on both antibiotic therapy and alternative approaches to combat the pathogen and manage symptoms.

Key Insights:

Fluoroquinolones and third-generation cephalosporins show high cure rates for Salmonella meningitis, with fluoroquinolones achieving an 88.9% cure rate and cephalosporins 84.6%, outperforming conventional antibiotics like chloramphenicol, ampicillin, and cotrimoxazole.
Ciprofloxacin, a fluoroquinolone, has been successfully used to treat Salmonella dublin infection in a prosthetic vascular graft, suggesting its efficacy in specific, localized infections.
Combined therapy using antimicrobial agents followed by cultured cecal bacteria has shown effectiveness in treating Salmonella infection in chickens, indicating a potential for combined therapeutic strategies.
Probiotics have emerged as an alternative treatment strategy, with evidence suggesting their effectiveness in preventing or treating Salmonella infections through immune modulation and non-immune mechanisms .
Prolonged antibiotic treatment, sometimes in conjunction with surgical intervention, has been effective in treating Salmonella infections of the abdominal aorta, highlighting the importance of duration and combination of therapies for certain infections .
Antibiotic therapy for non-severe Salmonella gut infections in otherwise healthy individuals may not provide clinical benefits and could lead to more adverse effects and prolonged Salmonella detection in stools.

Conclusion: The treatment of Salmonella infections varies depending on the severity and location of the infection. While fluoroquinolones and third-generation cephalosporins are effective for severe cases like meningitis, localized infections may be treated with specific antibiotics such as ciprofloxacin. Combined therapies and probiotics offer alternative strategies, particularly for non-severe cases where antibiotics may not be beneficial and could lead to adverse effects. The duration and combination of treatments are crucial factors in the management of more complex infections.

How is salmonella infection treated?

Summary

Sources and full results

Treatment of Salmonella meningitis: two case reports and a review of the literature.

Third-generation cephalosporins, with or without fluoroquinolones, may be the best option for treating Salmonella meningitis in children, with a cure rate of 84.6% compared to conventional antibiotics.

Salmonella dublin infection of a prosthetic vascular graft successfully treated with ciprofloxacin.

Salmonella dublin infection of a prosthetic vascular graft can be successfully treated with simple drainage and oral ciprofloxacin.

Combined therapy of Salmonella infection in chickens by antimicrobial agents followed by cultured cecal bacteria.

Combined therapy with oxytetracycline plus neomycin and bacterial culture is the most effective in treating Salmonella infection in chickens, as only antimicrobials can cause rapid recurrence.

Probiotics: An alternative strategy for combating salmonellosis: Immune mechanisms involved

Probiotics show potential in preventing and treating Salmonella infections through various mechanisms, including non-immune and immune responses.

Salmonella infection - prevention and treatment by antibiotics and probiotic yeasts: a review.

Probiotic yeasts show potential in preventing and treating Salmonella infections, but further studies are needed to determine their mechanisms, efficacy, and delivery methods.

Salmonella infections of the abdominal aorta cured with prolonged antibiotic treatment.

Prolonged antibiotic treatment combined with resection and in situ bypass grafting can successfully treat Salmonella infections of the abdominal aorta.

Abdominal aortic aneurysms infected with salmonella: problems of treatment.

In situ graft placement after extensive debridement and antibiotic therapy is a satisfactory surgical treatment for abdominal aortic aneurysms infected with salmonella, but regular follow-up is needed.

Chloromycetin in the treatment of salmonella enteritis.

Chloromycetin effectively treats salmonella enteritis in children, providing a promising alternative to sulfonamides and chemotherapeutic agents.

Ceftriaxone treatment of multidrug-resistant Salmonella osteomyelitis.

Ceftriaxone shows potential as an effective treatment for multidrug-resistant Salmonella osteomyelitis, suggesting its need for clinical trials.

Antibiotics for treating salmonella gut infections.

Antibiotic therapy shows no clinical benefit for healthy children and adults with non-severe salmonella diarrhoea, and may increase adverse effects and prolong salmonella detection in stools.

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