H. Takaku, Tetsuo Watanabe, S. Hamamoto
1988
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 1,1,1,3,3,3-Hexafluoro-2-propy(HFP) group is a new protecting group for the internucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite method. This group can be removed rapidly by oximate treatment. Further, we have found that the phosphitylating agent, bis(diisopropylamino)-1,1,1,3,3,3-hexafluoro-2-propoxyphosphine is easy to prepare in view of their stability during purification by distillation which not requires high vacuum.