Orit Jacobson, E. Mishani
Feb 1, 2008
Citations
0
Influential Citations
13
Citations
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Abstract
The dimethylamine functional group is a common component of the chemical structure of numerous drugs. The most commonly used synthetic route for carbon-11 labeled radiopharmaceuticals which contain the dimethylamine group is via C-11 methylation of the monomethyl amine precursors. Here we describe the radiosynthesis of [11C]dimethylamine (1) and its application in the direct labeling of several positron emission tomography (PET) imaging agents by-passing the preparation of the monomethyl amine precursors.