H. Eto, Y. Kaneko, S. Takeda
Feb 1, 2001
Citations
0
Influential Citations
51
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via alpha,alpha-difluoro-alpha-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and i.v. administrations. Especially, (-)-2a, (-)-2b and (-)-2d showed potent antifungal activities.