M. Holick, A. Pèrez, R. Raab
1992
Citations
0
Influential Citations
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Journal
Journal of nutritional science and vitaminology
Abstract
Twenty years ago the isolation and structural identification of the biologically active form of vitamin D as 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) heralded a new era in vitamin D research and its clinical application. The chemical synthesis of 1, 25(OH)2D3 eventually led to its clinical usefulness in a variety of inborn and acquired disorders in 25-hydroxyvitamin D3 (25-OH-D3) metabolism. In particular, patients with vitamin D dependent rickets type I and renal osteodystrophy showed remarkable improvement in their metabolic bone disease when treated with physiologic amounts of this hormone. 1, 25(OH)2D3 and its analog 1ƒ¿-hydroxyvitamin D3 (1ƒ¿-OH-D3) has also been widely used for the treatment of osteoporosis [1-3].