G. Bernhardt, R. Gust, H. Reile
2005
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Influential Citations
3
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Journal
Journal of Cancer Research and Clinical Oncology
Abstract
SummaryThe enantiomeric [1,2-bis(2-hydroxyphenyl)-ethylenediamine]dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a concentration of 2.5 μM. A difference between the enantiomers became evident from the faster onset of cytocidal activity of theS,S-configurated compound.