V. Y. Petukhova, N. Makhova, V. Ananikov
Mar 1, 2004
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0
Influential Citations
4
Citations
Journal
Russian Chemical Bulletin
Abstract
Using the synthesis of 1,2-bis(methylamino)ethane-1,2-diol dihydrochloride (5) as an example, it was demonstrated that aliphatic α-aminocarbinols can be stabilized as hydrochlorides. The reaction of compound 5 with N-chloromethylamine in CHCl3 in the presence of K2CO3 afforded 1,2,1",2"-tetramethyl-3,3"-bidiaziridine as a mixture of diastereomers (a racemate and a meso form). The meso form was isolated in the individual state and its structure was established by X-ray diffraction analysis. The kinetics of inversional epimerization was studied.