T. Avery, D. Caiazza, J. Culbert
Sep 21, 2005
Citations
0
Influential Citations
35
Citations
Journal
The Journal of organic chemistry
Abstract
A new method for the construction of tetrahydropyrans derived from readily available 1,2-dioxines containing a tethered hydroxyl moiety is described. The reaction proceeds via a base-catalyzed rearrangement of the 1,2-dioxines to either the isomeric cis or trans gamma-hydroxy enones followed by intramolecular oxa-Michael addition of the tethered hydroxyl group.