M. Tollefson, Brad A. Acker, E. Jacobsen
May 15, 2010
Citations
0
Influential Citations
23
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.