S. Saxena, M. Verma, A. Saxena
1992
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Indian Journal of Pharmaceutical Sciences
Abstract
5-[2-Hydroxy phenyl]-1,3,4-oxadiazole-2 (3H) thione (II) was synthesized by cyclization of salicylic acid hydrazide (I). II was further converted to 5-[2-hydroxy phenyl ]-3-[arylaminomethyl)-1,3,4-oxadiazole 2(3H) thiones (III) and their hydrochlorides (IV). All the compounds were evaluated for their ability to inhibit carrageenin induced rat's paw oedema. IIIc and IIIe were found to have better activity than phenylbutazone with higher ALD 50 values.